Catalogue / Retatrutide
Retatrutide
Also written as Triple agonist, LY3437943.
A triple GIP, GLP-1 and glucagon receptor agonist, structurally close enough to other members of the class that identity is a mass question and not a chromatographic one.
| Molecular formula | C221H342N46O68 |
| Average mass | 4731.35 Da |
| Monoisotopic mass | 4728.4718 Da |
| Class | Incretin analogues |
| Determination | Blind identification, GLP-1 class |
| Price | 468 USD |
Computed at build time from the composition shown on this page, not transcribed from a supplier datasheet.
Retatrutide has an average molecular weight of 4731.35 daltons and a monoisotopic mass of 4728.4718 daltons. Identity is confirmed by matching the measured deconvoluted mass to that figure, and purity is reported separately by reversed-phase chromatography at 214 nm. The two numbers answer different questions and neither substitutes for the other.
| Charge | m/z |
|---|---|
| [M+3H]3+ | 1577.165 |
| [M+4H]4+ | 1183.125 |
| [M+5H]5+ | 946.702 |
These are the ions an electrospray source is expected to produce for a neutral mass of 4728.4718 daltons, computed from the monoisotopic mass and the proton mass. They are what a raw spectrum should show before deconvolution.
A report that gives only a deconvoluted mass without the charge states it was derived from cannot be checked. Deconvolution is a calculation, and a calculation whose inputs are not shown is an assertion.
| Material sold under this name is among the most frequently misidentified in the peptide market. A blind determination against a panel of class standards is the only result that means anything. |
| Mass alone within one dalton is not conclusive between certain analogue pairs. Fragmentation or a co-injection against a certified standard resolves it. |
| The lipid side chain drives the same adsorption losses seen across the class, so spike recovery belongs on the certificate. |
Every compound fails in its own way. A generic peptide method applied without regard to these specifics produces a number that looks like a result and is not one.
Long-acting GLP-1 and dual agonists carrying a fatty acid chain on a lysine side chain. The class is chemically crowded, and analogues differ by a single substitution or a linker length.
LC-MS on the multiply charged envelope with deconvolution to the neutral mass, because analogues in this class co-elute closely and a retention-time match cannot separate them. Purity by RP-HPLC at 214 nm with a shallow acetonitrile gradient.
Where the delivered milligram figure matters rather than the percentage, net peptide content by combustion analysis and water by Karl Fischer are added, and the certificate carries a closed mass balance instead of a single purity number.
| LC-MS identity | Measured mass |
| RP-HPLC purity | Area at 214 nm |
| Net peptide content | Milligrams |
| Water content | Karl Fischer |
| Counter-ion | Ion chromatography |
| Bacterial endotoxins | USP <85> |
What is the molecular weight of Retatrutide?
The average molecular weight is 4731.35 daltons and the monoisotopic mass is 4728.4718 daltons, computed from the molecular formula C221H342N46O68 shown on this page. Both figures are calculated rather than transcribed, so they can be checked against the stated composition.
How is Retatrutide tested for purity and identity?
LC-MS on the multiply charged envelope with deconvolution to the neutral mass, because analogues in this class co-elute closely and a retention-time match cannot separate them. Purity by RP-HPLC at 214 nm with a shallow acetonitrile gradient. Purity describes the chromatographable fraction only and is not the same quantity as the peptide mass delivered per vial.
What goes wrong when Retatrutide is analysed?
Material sold under this name is among the most frequently misidentified in the peptide market. A blind determination against a panel of class standards is the only result that means anything.
What does Retatrutide analysis cost at ANALYTON?
Blind identification, GLP-1 class is priced at 468 US dollars, covering the determinations described on this page. Content, safety and elemental determinations are ordered alongside and are priced separately on the price list.
Other compounds in this class
Updated 2026-09-01. Masses computed at build, not transcribed.