Catalogue / LGD-4033
LGD-4033
Also written as Ligandrol, VK5211, Anabolicum.
A pyrrolidinyl benzonitrile carrying six fluorines and no chlorine, supplied as a single stereoisomer.
| Molecular formula | C14H12F6N2O |
| Average mass | 338.25 Da |
| Monoisotopic mass | 338.0854 Da |
| Molecular target | Androgen receptor |
| Electrospray polarity | Negative |
| Class | Androgen receptor modulators |
| Determination | Small molecule analysis, catalogue compound |
| Price | 267 USD |
Computed at build time from the composition shown on this page, not transcribed from a supplier datasheet.
LGD-4033 has an average molecular weight of 338.25 daltons and a monoisotopic mass of 338.0854 daltons, computed from the molecular formula C14H12F6N2O. Identity is confirmed by matching the measured mass against a certified reference standard, and purity is reported separately by reversed-phase chromatography at the compound's own ultraviolet maximum rather than at the 214 nm used for peptides. Neither figure states which enantiomer is present, which is a third determination on a chiral stationary phase.
| Ion | m/z |
|---|---|
| [M+H]+ | 339.0927 |
| [M-H]- | 337.0781 |
Usable response for this compound is in negative mode. The other ion is given because it is the one a wrongly configured method looks for.
A molecule of this size does not produce the multiply charged envelope a peptide does. It produces one singly charged ion, and which polarity that ion appears in is decided by the functional groups rather than by convenience. A nitro or cyano aromatic responds in negative mode; a basic amine responds in positive.
That is why a screen acquired in a single polarity misses part of its own compound list, and why a non-detect from such a screen is not evidence that a substance is absent. The polarity used belongs on the certificate alongside the result.
| Six fluorines and no chlorine means no M plus 2 isotope satellite. A chlorine isotope pattern in the spectrum of material sold under this name is by itself sufficient to rule the compound out, before any standard is consulted. |
| The name differs from LGD-3033 by one digit, and the two are different scaffolds four daltons apart in average mass. A substitution between them is invisible on a label, invisible on a retention time, and obvious on a spectrum. |
| A single stereoisomer, so an achiral purity figure can read high on material that is half the wrong isomer. Chiral purity is a separate determination and is reported separately. |
Every compound fails in its own way. A generic peptide method applied without regard to these specifics produces a number that looks like a result and is not one.
Non-steroidal small molecules, most of them a single enantiomer of an aryl propanamide. They are not peptides and almost nothing carried over from peptide work applies: there is no amide backbone to detect at 214 nm, the molecules are a fraction of the mass of the smallest peptide in this catalogue, and the impurity that matters most is a mirror image that no achiral column separates from the target.
LC-MS identity against a certified reference standard, acquired in the ionisation polarity the compound actually responds in rather than in whichever polarity the instrument was left in. Purity by HPLC-UV at the compound's own absorbance maximum, not at 214 nm. Enantiomeric purity is a separate determination on a chiral stationary phase and is reported as a separate figure, because an achiral method cannot see it.
Where the delivered milligram figure matters rather than the percentage, assay against a certified reference standard gives content directly, and where no such standard exists quantitative NMR against a certified internal standard gives an absolute purity that needs no standard of the analyte at all.
| LC-MS identity | Measured mass |
| HPLC-UV purity | Area at the UV maximum |
| Enantiomeric purity | Chiral stationary phase |
| Water content | Karl Fischer |
| Elemental impurities | ICP-MS |
| Residual solvents | GC-MS |
What is the molecular weight of LGD-4033?
The average molecular weight is 338.25 daltons and the monoisotopic mass is 338.0854 daltons, computed from the molecular formula C14H12F6N2O shown on this page. Both figures are calculated rather than transcribed, so they can be checked against the stated composition.
How is LGD-4033 tested for purity and identity?
LC-MS identity against a certified reference standard, acquired in the ionisation polarity the compound actually responds in rather than in whichever polarity the instrument was left in. Purity by HPLC-UV at the compound's own absorbance maximum, not at 214 nm. Enantiomeric purity is a separate determination on a chiral stationary phase and is reported as a separate figure, because an achiral method cannot see it. Purity is an area ratio measured at the compound's own ultraviolet maximum, and it describes the chromatographable fraction only. It says nothing about which enantiomer is present, because mirror images are not separated by an achiral column.
What goes wrong when LGD-4033 is analysed?
Six fluorines and no chlorine means no M plus 2 isotope satellite. A chlorine isotope pattern in the spectrum of material sold under this name is by itself sufficient to rule the compound out, before any standard is consulted.
What does LGD-4033 analysis cost at ANALYTON?
Small molecule analysis, catalogue compound is priced at 267 US dollars, covering the determinations described on this page. Content, safety and elemental determinations are ordered alongside and are priced separately on the price list.
Updated 2026-09-01. Masses computed at build, not transcribed.