Catalogue / AOD-9604
AOD-9604
Also written as hGH fragment 176-191, Tyr-hGH 177-191.
A sixteen residue C-terminal fragment of human growth hormone with an added N-terminal tyrosine and an internal disulfide bridge.
| Molecular formula | C78H123N23O23S2 |
| Average mass | 1815.08 Da |
| Monoisotopic mass | 1813.8604 Da |
| Residues | 16 |
| Termini | C-terminal free acid, 1 disulfide bridge |
| Class | Repair and regenerative peptides |
| Determination | Peptide analysis, specialist compound |
| Price | 590 USD |
Computed at build time from the composition shown on this page, not transcribed from a supplier datasheet.
AOD-9604 has an average molecular weight of 1815.08 daltons and a monoisotopic mass of 1813.8604 daltons. Identity is confirmed by matching the measured deconvoluted mass to that figure, and purity is reported separately by reversed-phase chromatography at 214 nm. The two numbers answer different questions and neither substitutes for the other.
| One letter | YLRIVQCRSVEGSCGF |
| Three letter | Tyr-Leu-Arg-Ile-Val-Gln-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe |
| Modifications | C-terminal free acid, 1 disulfide bridge |
The formula and both masses in the table above are derived from this sequence and these terminal modifications. A reader who believes a figure is wrong can check the composition rather than take the number on trust, which is the point of publishing it this way.
A sequence is not an identity result. It is the expected composition against which a measured mass is compared, and the comparison is what appears on the certificate.
| Charge | m/z |
|---|---|
| [M+1H]+ | 1814.868 |
| [M+2H]2+ | 907.937 |
| [M+3H]3+ | 605.627 |
These are the ions an electrospray source is expected to produce for a neutral mass of 1813.8604 daltons, computed from the monoisotopic mass and the proton mass. They are what a raw spectrum should show before deconvolution.
A report that gives only a deconvoluted mass without the charge states it was derived from cannot be checked. Deconvolution is a calculation, and a calculation whose inputs are not shown is an assertion.
| The disulfide between the two cysteines must be closed. The reduced linear form is two daltons heavier and is a common synthesis endpoint if the oxidation step was incomplete. |
| The added N-terminal tyrosine distinguishes this compound from the native fragment. Material lacking it is 163 daltons lighter. |
| Free thiols from incomplete oxidation drive intermolecular dimerisation on storage, which size exclusion sees and purity does not. |
Every compound fails in its own way. A generic peptide method applied without regard to these specifics produces a number that looks like a result and is not one.
Fragment peptides derived from larger endogenous proteins. Because they are fragments, a supplier can ship a shorter truncation that still looks correct on a chromatogram.
LC-MS identity with deconvolution, purity by RP-HPLC at 214 nm, and net peptide content where the delivered milligram figure matters.
Where the delivered milligram figure matters rather than the percentage, net peptide content by combustion analysis and water by Karl Fischer are added, and the certificate carries a closed mass balance instead of a single purity number.
| LC-MS identity | Measured mass |
| RP-HPLC purity | Area at 214 nm |
| Net peptide content | Milligrams |
| Water content | Karl Fischer |
| Counter-ion | Ion chromatography |
| Bacterial endotoxins | USP <85> |
What is the molecular weight of AOD-9604?
The average molecular weight is 1815.08 daltons and the monoisotopic mass is 1813.8604 daltons, computed from the sequence YLRIVQCRSVEGSCGF shown on this page. Both figures are calculated rather than transcribed, so they can be checked against the stated composition.
How is AOD-9604 tested for purity and identity?
LC-MS identity with deconvolution, purity by RP-HPLC at 214 nm, and net peptide content where the delivered milligram figure matters. Purity describes the chromatographable fraction only and is not the same quantity as the peptide mass delivered per vial.
What goes wrong when AOD-9604 is analysed?
The disulfide between the two cysteines must be closed. The reduced linear form is two daltons heavier and is a common synthesis endpoint if the oxidation step was incomplete.
What does AOD-9604 analysis cost at ANALYTON?
Peptide analysis, specialist compound is priced at 590 US dollars, covering the determinations described on this page. Content, safety and elemental determinations are ordered alongside and are priced separately on the price list.
Other compounds in this class
Updated 2026-09-01. Masses computed at build, not transcribed.